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Applied Mathematical Physiology Laboratory (AMP Lab)

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The Applied Mathematical Physiology Laboratory is part of the Dpt. of Anesthesiology and Intensive Care Medicine, University of Bonn Medical Center (Director: Prof. Dr. Andreas Hoeft).

Head of research group: PD Dr. med. Sven Zenker

 We focus on utilizing mathematical models of physiology and pathopyhsiology to quantitatively interpret monitoring data from acute care settings. The mid-term goal is the fully individualized quantitative prediction and optimized therapeutic control of critical illness trajectories exploiting all quantitative data available for a patient. In addition to developing mathematical models optimized for these application scenarios, we focus on the complete quantification of uncertainty in the solutions of the practically relevant parameter and state estimation problems and the resulting predictions arising in this context by applying probabilistic solution techniques to the underlying inverse problem.

This work has been supported, among others, by the Deutsche Forschungsgemeinschaft (DFG), the National Institutes of Health (NIH), USA, the German-Israeli-Foundation (GIF), and the Dräger Foundation.


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